Parenterals & Injectables

Biography

Biography: Panayiotis P Constantinides

Abstract

There have been major advances and achievements in the use of nanoparticles for parenteral drug delivery and targeting especially for cancer drugs and biologics. Of particular interest are drug nanodispersions and include, liposomes, nanoemulsions, solid lipid nanoparticles, polymeric micelles, dendrimers, nanocrystals and nanosuspensions. Directing therapeutics to intracellular targets and selectively killing disease cells is the primary driving force behind the rapid evolution of nanoparticle-based approaches. A brief overview of nanoparticle design, manufacturing, characterization and in vitro/in vivo assessment, including Quality-by-Design (QbD) aspects, will be discussed during the first part of the talk. Case studies will then be presented with parenteral small molecules, approved drugs or New Molecular Entities (NMEs) employing nanoemulsions, liposomes, polymeric micelles and solid lipid nanoparticles. Improvements in the manufacturing methods and better understanding of the factors controlling stability will certainly expand the use of nanodispersions in parenteral drug